Evaluating Polygenic Risk Scores for Breast Cancer in Women of African Ancestry

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Authors

Zhaohui Du · University of Southern California

Guimin Gao · Chicago Department of Public Health

Babatunde Adedokun · Chicago Department of Public Health

Thomas U. Ahearn · National Institutes of Health

Kathryn L. Lunetta · Boston University

Gary Zirpoli · Boston University

Melissa A. Troester

Abstract

The PRSs stratify BC risk in women of African ancestry, with attenuated performance compared with that reported in European, Asian, and Latina populations. Future work is needed to improve BC risk stratification for women of African ancestry.

Topics & Keywords

BRCA gene mutations in cancer Global Cancer Incidence and Screening Cancer Genomics and Diagnostics

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 113, Issue 9, pp. 1168-1176

DOI: 10.1093/jnci/djab050

Field-Weighted Citation Impact: 10.04

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Evaluating Polygenic Risk Scores for Breast Cancer in Women of African Ancestry

Authors

Abstract

Topics & Keywords

Publication Details