Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

2021132 citationsJournal Articlegreen Open Access

Authors

Gabriëlla A.M. Blokland · Broad Institute

Jakob Grove · Aarhus University

Chia‐Yen Chen · Biogen (United States)

Chris Cotsapas · Broad Institute

Stuart Tobet · Massachusetts General Hospital

Robert J. Handa · Massachusetts General Hospital

Stephan Ripke · University of Aberdeen

Abstract

In the largest genome-wide G×S analysis of mood and psychotic disorders to date, there was substantial genetic overlap between the sexes. However, significant sex-dependent effects were enriched for genes related to neuronal development and immune and vascular functions across and within SCZ, BIP, and MDD at the variant, gene, and pathway levels.

Topics & Keywords

Receptor Mechanisms and Signaling Genetic Associations and Epidemiology Circadian rhythm and melatonin

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Biological Psychiatry

Volume 91, Issue 1, pp. 102-117

DOI: 10.1016/j.biopsych.2021.02.972

Field-Weighted Citation Impact: 7.81