Proof-of-Mechanism Study of the Phosphodiesterase 10 Inhibitor RG7203 in Patients With Schizophrenia and Negative Symptoms

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Authors

Daniel Umbricht · Roche (Switzerland)

Markus Abt · Roche (Switzerland)

Paul Tamburri

Christopher H. Chatham · Roche (Switzerland)

Štefan Holiga · Roche (Switzerland)

Michael J. Frank · Allen Institute for Brain Science

Anne Collins · University of California, Berkeley

Abstract

In contrast to our expectations, RG7203 significantly worsened reward-based effortful behavior and indices of reward learning. The results do not support the utility of RG7203 as adjunctive treatment for negative symptoms in patients with schizophrenia.

Topics & Keywords

Phosphodiesterase function and regulation Schizophrenia research and treatment Blood Pressure and Hypertension Studies

Publication Details

Published in: Biological Psychiatry Global Open Science

Volume 1, Issue 1, pp. 70-77

DOI: 10.1016/j.bpsgos.2021.03.001

Field-Weighted Citation Impact: 0.81

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Proof-of-Mechanism Study of the Phosphodiesterase 10 Inhibitor RG7203 in Patients With Schizophrenia and Negative Symptoms

Authors

Abstract

Topics & Keywords

Publication Details