Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma

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Authors

Jie Yu · Shanghai Ninth People's Hospital

Peiwei Chai · Shanghai Jiao Tong University

Minyue Xie · Shanghai Ninth People's Hospital

Shengfang Ge · Shanghai Jiao Tong University

Jing Ruan · Shanghai Ninth People's Hospital

Xianqun Fan · Shanghai Ninth People's Hospital

Renbing Jia

Abstract

We reveal the oncogenic role of histone lactylation, thereby providing novel therapeutic targets for ocular melanoma therapy. We also bridge histone modifications with RNA modifications, which provides novel understanding of epigenetic regulation in tumorigenesis.

Topics & Keywords

RNA modifications and cancer Peptidase Inhibition and Analysis Epigenetics and DNA Methylation

Publication Details

Published in: Genome biology

Volume 22, Issue 1, pp. 85-85

DOI: 10.1186/s13059-021-02308-z

Field-Weighted Citation Impact: 46.93

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Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma

Authors

Abstract

Topics & Keywords

Publication Details