Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination

20212,257 citationsJournal Articlebronze Open Access

Authors

Andreas Greinacher · Universitätsmedizin Greifswald

Thomas Thiele · Universitätsmedizin Greifswald

Theodore E. Warkentin · Universitätsmedizin Greifswald

Karin Weißer · Universitätsmedizin Greifswald

Paul A. Kyrle · Universitätsmedizin Greifswald

Sabine Eichinger · Universitätsmedizin Greifswald

Abstract

Vaccination with ChAdOx1 nCov-19 can result in the rare development of immune thrombotic thrombocytopenia mediated by platelet-activating antibodies against PF4, which clinically mimics autoimmune heparin-induced thrombocytopenia. (Funded by the German Research Foundation.).

Topics & Keywords

Heparin-Induced Thrombocytopenia and Thrombosis Platelet Disorders and Treatments Intramuscular injections and effects

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 384, Issue 22, pp. 2092-2101

DOI: 10.1056/nejmoa2104840

Field-Weighted Citation Impact: 436.33