Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment

2021190 citationsJournal Article

Authors

Zhibo Xie · Fudan University

Ya Gao · Shanghai Jiao Tong University

Chiakang Ho · Shanghai Jiao Tong University

Le‐Qun Li · Tumor Hospital of Guangxi Medical University

Jin Chen · Fudan University

Xiaoyi Wang · Fudan University

Caifeng Zou ·

Abstract

The Pex-derived CD44v6/C1QBP complex is essential for the formation of a fibrotic liver microenvironment and PDAC liver metastasis. Highly expressed exosomal CD44v6 and C1QBP are promising biomarkers for predicting prognosis and liver metastasis in patients with PDAC.

Topics & Keywords

Extracellular vesicles in disease MicroRNA in disease regulation Phagocytosis and Immune Regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gut

Volume 71, Issue 3, pp. 568-579

DOI: 10.1136/gutjnl-2020-323014

Field-Weighted Citation Impact: 13.88