Cardiac Late Sodium Channel Current Is a Molecular Target for the Sodium/Glucose Cotransporter 2 Inhibitor Empagliflozin

2021192 citationsJournal Articlehybrid Open Access

Authors

Koenraad Philippaert · Juvenile Diabetes Research Foundation

Subha Kalyaanamoorthy · University of Alberta

Mohammad Fatehi · University of Alberta

Wentong Long · University of Alberta

Shubham Soni · University of Alberta

Nikole J. Byrne · University of Alberta

Amy Barr ·

Abstract

Our results provide evidence that late-<i>I</i><sub>Na</sub> may be an important molecular target in the heart for the SGLT2 inhibitors, contributing to their unexpected cardioprotective effects.

Topics & Keywords

Diabetes Treatment and Management Pancreatic function and diabetes Cardiac electrophysiology and arrhythmias

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 143, Issue 22, pp. 2188-2204

DOI: 10.1161/circulationaha.121.053350

Field-Weighted Citation Impact: 22.45