Loss‐of‐Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia

2021114 citationsJournal Articlehybrid Open Access

Authors

Yi Niu · Sun Yat-sen University

Ziyou Lin · Sun Yat-sen University

Arabella Wan · Sun Yat-sen University

Lei Sun · Sun Yat-sen University

Shijia Yan · Sun Yat-sen University

Heng Liang · Sun Yat-sen University

Siyue Zhan · Sun Yat-sen University

Abstract

Our work identifies ALDOA as an essential driver for HCC cell growth under hypoxia, and we demonstrate that inhibition of ALDOA in the hypoxic TME is a promising therapeutic strategy for treating HCC.

Topics & Keywords

Cancer, Hypoxia, and Metabolism Epigenetics and DNA Methylation RNA modifications and cancer

Publication Details

Published in: Hepatology

Volume 74, Issue 3, pp. 1461-1479

DOI: 10.1002/hep.31846

Field-Weighted Citation Impact: 8.91

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Loss‐of‐Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia

Authors

Abstract

Topics & Keywords

Publication Details