Glucocorticoids and B Cell Depleting Agents Substantially Impair Immunogenicity of mRNA Vaccines to SARS-CoV-2

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Authors

Parakkal Deepak · Washington University in St. Louis

Wooseob Kim · Washington University in St. Louis

Michael Paley · Washington University in St. Louis

Monica Yang · University of California, San Francisco

Alexander Carvidi · University of California, San Francisco

Alia A. El‐Qunni · Washington University in St. Louis

Alem Haile

Abstract

CID patients treated with immunosuppressive therapies exhibit impaired SARS-CoV-2 vaccine-induced immunity, with glucocorticoids and B cell depletion therapy more severely impeding optimal responses.

Topics & Keywords

SARS-CoV-2 and COVID-19 Research Immunotherapy and Immune Responses Heparin-Induced Thrombocytopenia and Thrombosis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: medRxiv

DOI: 10.1101/2021.04.05.21254656