G-quadruplexes are transcription factor binding hubs in human chromatin

2021264 citationsJournal Articlegold Open Access

Authors

Jochen Spiegel · Cancer Research UK

Sergio Martínez Cuesta · University of Cambridge

Santosh Adhikari · University of Cambridge

Robert Hänsel‐Hertsch · University of Cologne

David Tannahill · Cancer Research UK

Shankar Balasubramanian · University of Cambridge

Abstract

Our results reveal a novel non-canonical mechanism for TF binding whereby G4s operate as common binding hubs for many different TFs to promote increased transcription.

Topics & Keywords

DNA and Nucleic Acid Chemistry Advanced biosensing and bioanalysis techniques RNA Interference and Gene Delivery

Publication Details

Published in: Genome biology

Volume 22, Issue 1, pp. 117-117

DOI: 10.1186/s13059-021-02324-z

Field-Weighted Citation Impact: 14.80

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G-quadruplexes are transcription factor binding hubs in human chromatin

Authors

Abstract

Topics & Keywords

Publication Details