Zinc attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury by activating Nrf2/GPX4 defense pathway

2021251 citationsJournal Articlegold Open Access

Authors

Minghao Ge · Jinzhou Medical University

He Tian · Jinzhou Medical University

Liang Mao · Jinzhou Medical University

Daoyong Li · Jinzhou Medical University

Jiaquan Lin · Jinzhou Medical University

Hengshuo Hu · Jinzhou Medical University

Shuocheng Huang ·

Abstract

Zinc promoted the degradation of oxidative stress products and lipid peroxides through the NRF2/HO-1 and GPX4 signaling pathways to inhibit ferroptosis in neurons.

Topics & Keywords

Spinal Cord Injury Research Pregnancy-related medical research Peroxisome Proliferator-Activated Receptors

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: CNS Neuroscience & Therapeutics

Volume 27, Issue 9, pp. 1023-1040

DOI: 10.1111/cns.13657

Field-Weighted Citation Impact: 27.67