Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With Cardiovascular Disease

2021117 citationsJournal Articlehybrid Open Access

Authors

Nadia Akawi · United Arab Emirates University

Antonio Checa · Karolinska Institutet

Alexios S. Antonopoulos · University of Oxford

Ioannis Akoumianakis · University of Oxford

Evangelia Daskalaki · Karolinska Institutet

Christos P. Kotanidis · University of Oxford

Hidekazu Kondo ·

Abstract

These results demonstrate for the first time in humans that AT-derived ceramides are modifiable regulators of vascular redox state in obesity, with a direct impact on cardiac mortality in advanced atherosclerosis. (The Interaction Between Appetite Hormones; NCT02094183).

Topics & Keywords

Cardiovascular Disease and Adiposity Cardiovascular, Neuropeptides, and Oxidative Stress Research Adipokines, Inflammation, and Metabolic Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of the American College of Cardiology

Volume 77, Issue 20, pp. 2494-2513

DOI: 10.1016/j.jacc.2021.03.314

Field-Weighted Citation Impact: 15.38