A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts

2021198 citationsJournal Articlegreen Open Access

Authors

Guiyan Ni · The University of Queensland

Jian Zeng · The University of Queensland

Joana Revez · The University of Queensland

Ying Wang · The University of Queensland

Zhili Zheng · The University of Queensland

Tian Ge · Massachusetts General Hospital

Restuadi Restuadi ·

Abstract

Although the methods that more formally model genetic architecture have similar performance, MegaPRS, LDpred2, and SBayesR rank highest in most comparisons and are recommended in applications to psychiatric disorders.

Topics & Keywords

Genetic Associations and Epidemiology Advanced Causal Inference Techniques Liver Disease Diagnosis and Treatment

Publication Details

Published in: Biological Psychiatry

Volume 90, Issue 9, pp. 611-620

DOI: 10.1016/j.biopsych.2021.04.018

Field-Weighted Citation Impact: 27.22

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A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts

Authors

Abstract

Topics & Keywords

Publication Details