RNA Externalized by Neutrophil Extracellular Traps Promotes Inflammatory Pathways in Endothelial Cells

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Authors

Luz P. Blanco · National Institute of Arthritis and Musculoskeletal and Skin Diseases

Xinghao Wang · National Institute of Arthritis and Musculoskeletal and Skin Diseases

Philip M. Carlucci · National Institute of Arthritis and Musculoskeletal and Skin Diseases

Jiram Torres‐Ruiz · National Institute of Arthritis and Musculoskeletal and Skin Diseases

Jorge Romo‐Tena · National Institute of Arthritis and Musculoskeletal and Skin Diseases

Hong‐Wei Sun · National Institute of Arthritis and Musculoskeletal and Skin Diseases

Abstract

These findings highlight underappreciated roles for small RNAs externalized in NETs in the induction of proinflammatory responses in vascular cells, with implications for lupus vasculopathy.

Topics & Keywords

Neutrophil, Myeloperoxidase and Oxidative Mechanisms Cell Adhesion Molecules Research Immune Response and Inflammation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Arthritis & Rheumatology

Volume 73, Issue 12, pp. 2282-2292

DOI: 10.1002/art.41796

Field-Weighted Citation Impact: 3.27