Impact of chronic obstructive pulmonary disease on immune checkpoint inhibitor efficacy in advanced lung cancer and the potential prognostic factors

202153 citationsJournal Articlediamond Open Access

Authors

Jiebai Zhou · Fudan University

Yencheng Chao · Fudan University

Danwei Yao · Johns Hopkins University

Ning Ding · Sun Yat-sen University

Jiamin Li · Zhongshan Hospital

Lei Gao · The First Affiliated Hospital, Sun Yat-sen University

Yong Zhang ·

Abstract

COPD was associated with better survival in advanced-stage lung cancer patients treated with ICIs. Plasma IL-8 and IL-2R levels were potential prognostic factors for clinical outcome. The nomograms represent a possibly useful tool for predicting the clinical outcomes of immunotherapy.

Topics & Keywords

Cancer Immunotherapy and Biomarkers Lung Cancer Diagnosis and Treatment Chronic Obstructive Pulmonary Disease (COPD) Research

UN Sustainable Development Goals

No poverty

Publication Details

Published in: Translational Lung Cancer Research

Volume 10, Issue 5, pp. 2148-2162

DOI: 10.21037/tlcr-21-214

Field-Weighted Citation Impact: 3.31