Four Common Late-Life Cognitive Trajectories Patterns Associate with Replicable Underlying Neuropathologies

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Authors

Shama D. Karanth · University of Kentucky

Frederick A. Schmitt · University of Kentucky

Peter T. Nelson · University of Kentucky

Yuriko Katsumata · University of Kentucky

Richard J. Kryscio · University of Kentucky

David W. Fardo · University of Kentucky

Jordan P. Harp ·

Abstract

Cognitive trajectories associated strongly with neuropathology, particularly Braak NFT stage. High frequency of multiple pathologies in trajectories with cognitive decline suggests dementia treatment and prevention efforts must consider multiple diseases simultaneously.

Topics & Keywords

Dementia and Cognitive Impairment Research Alzheimer's disease research and treatments Frailty in Older Adults

Publication Details

Published in: Journal of Alzheimer s Disease

Volume 82, Issue 2, pp. 647-659

DOI: 10.3233/jad-210293

Field-Weighted Citation Impact: 2.42

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Four Common Late-Life Cognitive Trajectories Patterns Associate with Replicable Underlying Neuropathologies

Authors

Abstract

Topics & Keywords

Publication Details