Prognostic Significance of Blood-Based Multi-cancer Detection in Plasma Cell-Free DNA

2021117 citationsJournal Articlehybrid Open Access

Authors

Xiaoji Chen · Meta (United States)

Dong Zhao · Meta (United States)

Earl Hubbell · Meta (United States)

Kathryn N. Kurtzman · Meta (United States)

Geoffrey R. Oxnard · Dana-Farber Cancer Institute

Oliver Venn · Meta (United States)

Collin Melton ·

Abstract

Cancer detection by the MCED test was prognostic beyond clinical stage and method of diagnosis. Cancers not detected by the MCED test had better prognosis than cancers detected and SEER-based expected survival. Cancer detection and prognosis may be linked by the underlying biological factor of tumor fraction in cfDNA.

Topics & Keywords

Cancer Genomics and Diagnostics Viral-associated cancers and disorders Cholangiocarcinoma and Gallbladder Cancer Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 27, Issue 15, pp. 4221-4229

DOI: 10.1158/1078-0432.ccr-21-0417

Field-Weighted Citation Impact: 7.43