Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies

2021258 citationsJournal Articlegreen Open Access

Authors

Qibin Qi · Albert Einstein College of Medicine

Jun Li · Harvard University

Bing Yu · The University of Texas Health Science Center at Houston

Jee‐Young Moon · Albert Einstein College of Medicine

Jin Choul Chai · Albert Einstein College of Medicine

Jordi Merino · Harvard University

Jie Hu

Abstract

Higher milk intake among lactase non-persistent individuals, and higher fibre intake were associated with a favourable profile of circulating tryptophan metabolites for T2D, potentially through the host-microbial cross-talk shifting tryptophan metabolism toward gut microbial indolepropionate production.

Topics & Keywords

Gut microbiota and health Diet and metabolism studies Nutritional Studies and Diet

Publication Details

Published in: Gut

Volume 71, Issue 6, pp. 1095-1105

DOI: 10.1136/gutjnl-2021-324053

Field-Weighted Citation Impact: 13.83

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Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies

Authors

Abstract

Topics & Keywords

Publication Details