LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis

2021114 citationsJournal Article

Authors

Huijing Yu · XinHua Hospital

Fang Zhang · XinHua Hospital

Pengyi Yan · XinHua Hospital

Shasha Zhang · XinHua Hospital

Yingmei Lou · XinHua Hospital

Zilong Geng · XinHua Hospital

Zixuan Li · XinHua Hospital

Abstract

LARP7 is essential for mitochondrial biogenesis, energy production, and cardiac function by modulating SIRT1 homeostasis and activity. Reduction of LARP7 in diseased hearts owing to activation of the ATM pathway contributes to HF pathogenesis and restoring LARP7 in the injured heart confers myocardial protection. These results identify the ATM-LARP7-SIRT1 pathway as a target for therapeutic intervention in HF.

Topics & Keywords

PARP inhibition in cancer therapy Viral Infections and Immunology Research RNA regulation and disease

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 143, Issue 20, pp. 2007-2022

DOI: 10.1161/circulationaha.120.050812

Field-Weighted Citation Impact: 6.08