SUBTYPES OF MALIGNANT LYMPHOMAS IN UKRAINE, ACCORDING TO 2016 WHO CLASSIFICATION. PRELIMINARY REPORT OF THE UKRAINIAN LYMPHOMA REGISTRY

Introduction: According to the Ukrainian National Cancer Registry, Malignant Lymphoma (ML) represent the 9th most frequent type of cancer, with age-standardized rates of 8.4 for males and 6.6 for females. Unfortunately, no data on subtypes of ML are reported neither by WHO2008 nor the updated WHO2016 classification. There is a lack of information on real incidence, clinical presentation, outcome of different subtypes, and performances of the healthcare system in Ukraine. In 2019, the Ukrainian lymphoma registry (ULR) was established and here we report the preliminary analysis of the first 432 cases registered, based on local histological diagnosis. Methods: The ULR prospectively collects information on baseline clinical and disease characteristics, first-line treatment, and response evaluation of new cases of ML classified according to the most recent WHO2016 classification. Registration was performed on-line on a secured dedicated database. Electronic Case Report Forms were reviewed and verified by the ULR team. Results: ULR was launched in October, 2019. So far, 432 patients with newly diagnosed ML were registered. The median age is 45.9 years (range 17-99), 40,6% were male, and 59,4% - female. By age distribution, 20,6% of patients were under 30 years old, 37,8% between 30 - 49, 22,7% in 50- 64, while 18,9% were over 65. Overall, 64% of the population is affected by mature B-cell neoplasms, 32% by Hodgkin lymphoma and 4% by mature T and NK-cell neoplasms. As reported in Table 1, DLBCL (24.7% of cases) represents the most frequent subtype of B-cell malignancies, followed by CLL/SLL (7.7%) and FL (7.6%). A high incidence of PMBCL (7.0%) and PCNSL (4.6%), was observed. With respect to mature T and NK-cell lymphomas, ATLL and AITL resulted the most frequent sub-types. Conclusions: Our preliminary ULR data provides the first comprehensive analysis on the distribution pattern of ML in Ukraine, classified according to the recent WHO classification. As expected considering the Ukrainian population age structure, a high percentage of ML are represented by HL, while a limited number of FL have been found, suggesting a possible different genetic predisposition to this subtype in the Ukrainian population. In conclusion, regardless its very young age, ULR is recruiting very well and may help to better investigate the outcome of patients with ML outside clinical trials, in the real world. The research was funded by: Associazione Angela Serra for Cancer Research, Italy Keywords: Pathology and Classification of Lymphomas No conflicts of interests pertinent to the abstract.