Memory-like Differentiation Enhances NK Cell Responses to Melanoma

202175 citationsJournal Articlehybrid Open Access

Authors

Nancy D. Marín · Washington University in St. Louis

Bradley A. Krasnick · Washington University in St. Louis

Michelle Becker‐Hapak · Washington University in St. Louis

Leah Conant · Washington University in St. Louis

S. Peter Goedegebuure · Washington University in St. Louis

Melissa M. Berrien-Elliott · Washington University in St. Louis

Keenan J. Robbins

Abstract

Blood NK cells from allogeneic HD or patients with advanced melanoma can be differentiated into ML NK cells for use as a novel immunotherapeutic treatment for advanced melanoma, which warrants testing in early-phase clinical trials.

Topics & Keywords

Immune Cell Function and Interaction T-cell and B-cell Immunology CAR-T cell therapy research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 27, Issue 17, pp. 4859-4869

DOI: 10.1158/1078-0432.ccr-21-0851

Field-Weighted Citation Impact: 4.91