Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin

2021135 citationsJournal Articlegold Open Access

Authors

Kai Hou · Rutgers, The State University of New Jersey

Jianliang Shen · Rutgers, The State University of New Jersey

Junrong Yan · Rutgers, The State University of New Jersey

Chuannan Zhai · Nankai University

Jingxia Zhang · Tianjin Chest Hospital

Ji-An Pan · Sun Yat-sen University

Ye Zhang

Abstract

NIH (CA129536; DK108989): data collection, analysis. Shanghai Pujiang Program (19PJ1401900): data collection. National Natural Science Foundation (31971161): data collection. Department of Veteran Affairs (BX004083): data collection. Tianjin Science and Technology Plan Project (17ZXMFSY00020): data collection.

Topics & Keywords

Circular RNAs in diseases Chemotherapy-induced cardiotoxicity and mitigation Ferroptosis and cancer prognosis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: EBioMedicine

Volume 69, pp. 103456-103456

DOI: 10.1016/j.ebiom.2021.103456

Field-Weighted Citation Impact: 8.68