Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress

2021745 citationsReviewgold Open Access

Authors

Qing Zhang · Chengdu University of Traditional Chinese Medicine

Jia Liu · Chengdu University of Traditional Chinese Medicine

Huxinyue Duan · Chengdu University of Traditional Chinese Medicine

Ruolan Li · Chengdu University of Traditional Chinese Medicine

Wei Peng · Chengdu University of Traditional Chinese Medicine

Chunjie Wu · Chengdu University of Traditional Chinese Medicine

Abstract

Our present paper provides updated information of natural agents with protective activities on ECs against oxidative stress by activating Nrf2/HO-1. We hope this review will provide some directions for the further development of novel candidate drugs from natural agents for the treatment of AS and other CVDs.

Topics & Keywords

Atherosclerosis and Cardiovascular Diseases Antioxidant Activity and Oxidative Stress Inflammasome and immune disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Advanced Research

Volume 34, pp. 43-63

DOI: 10.1016/j.jare.2021.06.023

Field-Weighted Citation Impact: 37.50