An integrative network-based approach for drug target indication expansion

202118 citationsJournal Articlegold Open Access

Authors

Abstract

Our results demonstrated a potential global approach for indication expansion strategies. The proposed methodology enables rapid and systematic evaluation of both individual and combined drug targets for novel indications. Additionally, this approach provides novel insights on expanding the role of genes and pathways for developing therapeutic intervention strategies.

Topics & Keywords

Computational Drug Discovery Methods Bioinformatics and Genomic Networks Health Systems, Economic Evaluations, Quality of Life

Publication Details

Published in: PLoS ONE

Volume 16, Issue 7, pp. e0253614-e0253614

DOI: 10.1371/journal.pone.0253614

Field-Weighted Citation Impact: 1.96

Command Palette

An integrative network-based approach for drug target indication expansion

Authors

Abstract

Topics & Keywords

Publication Details