Abstract 842: Ethnic differences in association of behavioral risk factors with gastric precancerous lesions in Inner Mongolia, China

Abstract Background: The prevalence of Gastric precancerous lesion (GPL) exists ethnic differences, however, little evidence exists to clarify whether preventable behavioral risk factors lead to these differences. Objectives: To investigate the ethnic-difference of associations between GPL and behavioral risk factors in Mongol and Han Chinese population. Methods: The study included participants aged 36-75 years enrolling in the Cancer Screening Program during 2016-2017 from Hohhot and Tongliao City in Inner Mongolia. GPL defined as gastric ulcer, atrophic gastritis, intestinal metaplasia and dysplasia. Results: A total of 61638 participants were included, of whom 6863(11.1%) were Mongolians. The prevalence of GPL for Mongolians (13.6%) was significantly higher than that of Han (10.2%). Compared with Han: (1) Mongolians have significantly higher proportion of alcohol consumption (23.1% vs 18.8%), along with a larger positive association for alcohol consumption with GPL, and a higher population attributable fraction (PAF) (P<0.05); (2) Mongolians have significantly lower proportion of irregular physical activity (60.1% vs 62.3%), but with a larger positive association for irregular physical activity with GPL, and a higher PAF (P<0.05). (3) Mongolians have significantly lower proportion of insufficient vegetables and fruits intake (80.6% vs 82.2%), the significant association for insufficient vegetable and fruit intake with GPL was observed only in Mongolians (P < 0.05). (4) Mongolians have significantly higher proportion of smoking (23.1%), as the association for light smoking with GPL in Mongolians were lower than that in Han, resulting into similar PAF in two population. Conclusion: Mongolians should pay more attention to the intervention of behavioral risk factors. Additionally, the result may also reflect a different GPL pathogenesis in Mongolians. Association between behavioral risk factors and GPL in study populationBehavioral risk factorsExposure ratio (%) (95%CI)P for chi-square testOdd Ratio (95%CI )P for interactionPopulation attributable fraction (95%CI )Smoking (cigarettes/d)<0.01<0.01Han18.8 (18.5, 19.1)46.3 (44.6, 47.8)<104.9 (4.7, 5.1)5.2 (4.7, 5.9)11-207.8 (7.6, 8.0)8.2 (7.5, 9.0)≥216.1 (5.9, 6.3)7.1 (6.4, 7.8)Mongol23.1 (22.1, 24.1)43.4 (39.1, 47.4)<105.9 (5.3, 6.5)3.0 (2.2, 4.0)11-2010.9 (10.2, 11.7)6.2 (5.0, 7.7)≥216.3 (5.7, 6.9)7.0 (5.5, 9.1)Alcohol consumption<0.010.015Han18.8 (18.5, 19.2)5.6 (5.3, 6.0)43.7 (42.1, 45.3)Mongol25.1 (24.0, 26.1)6.9 (5.8, 8.3)53.2 (49.0, 57.0)irregular physical activity0.001<0.01Han62.3 (61.9, 62.7)1.1 (1.0, 1.2)5.6 (1.3, 9.8)Mongol60.1 (59.0, 61.3)2.0 (1.7,2.4)38.8 (30.5, 46.1)Insufficient vegetables and fruits intake0.0010.06Han82.2 (81.9, 82.5)1.0 (0.9,1.1)3.0 (-3.9, 9.5)Mongol80.6 (79.6, 81.5)1.3 (1.0,1.6)18.1 (2.5, 31.1) Citation Format: Weiqi Dong, Liying Qiao, Buqi Na, Weiwei Kang, Shengfeng Wang, Wenrui Wang, Yunfeng Xi. Ethnic differences in association of behavioral risk factors with gastric precancerous lesions in Inner Mongolia, China [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 842.