Identification and engraftment of new bacterial strains by shotgun metagenomic sequence analysis in patients with recurrent Clostridioides difficile infection before and after fecal microbiota transplantation and in healthy human subjects

202128 citationsJournal Articlegold Open Access

Authors

Sandeep Verma · Sinai Hospital

Sudhir Dutta · University of Maryland, Baltimore

Elad Firnberg · Sinai Hospital

Laila Phillips · Sinai Hospital

Rakesh Vinayek · Sinai Hospital

Padmanabhan P. Nair · Johns Hopkins University

Abstract

These observations identify a group of SCFA-producing bacterial strains from healthy donors that engraft well in patients with RCDI following FMT and are associated with complete resolution of clinical symptoms and bacterial dysbiosis.

Topics & Keywords

Clostridium difficile and Clostridium perfringens research Gut microbiota and health Helicobacter pylori-related gastroenterology studies

Publication Details

Published in: PLoS ONE

Volume 16, Issue 7, pp. e0251590-e0251590

DOI: 10.1371/journal.pone.0251590

Field-Weighted Citation Impact: 1.24

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Identification and engraftment of new bacterial strains by shotgun metagenomic sequence analysis in patients with recurrent Clostridioides difficile infection before and after fecal microbiota transplantation and in healthy human subjects

Authors

Abstract

Topics & Keywords

Publication Details