Tumor Extracellular Vesicles Regulate Macrophage-Driven Metastasis through CCL5

202140 citationsJournal Articlegold Open Access

Authors

Daniel C. Rabe · Broad Institute

Nykia D. Walker · University of Chicago

Felicia Rustandy · University of Chicago

Jessica C. Wallace · Harvard University

Jiyoung Lee · University of Chicago

Shannon L. Stott · Harvard University

Marsha Rich Rosner ·

Abstract

These results demonstrate that tumor-derived EVs are key mediators of macrophage education and likely play a more complex role in modulating tumor therapeutic response by regulating the tumor immune infiltrate.

Topics & Keywords

Extracellular vesicles in disease MicroRNA in disease regulation Immune cells in cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancers

Volume 13, Issue 14, pp. 3459-3459

DOI: 10.3390/cancers13143459

Field-Weighted Citation Impact: 2.52