A Systematic Review of Radiation-Related Lymphopenia in Genito-urinary Malignancies

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Authors

Thiraviyam Elumalai · Manchester University NHS Foundation Trust

Kannan Periasamy · Post Graduate Institute of Medical Education and Research

Ishwariya Rajendran · Pennine Acute Hospitals NHS Trust

Ambedkar Yedala · Jawaharlal Institute of Post Graduate Medical Education and Research

Prashanth Giridhar · Cancer Institute (WIA)

Rituraj Upadhya · The University of Texas MD Anderson Cancer Center

Abstract

One-third of the patients suffer from severe lymphopenia after radiation in prostate and bladder cancer. There are no clear data to support the correlation between severe lymphopenia and disease outcomes. Bone marrow dosimetry can affect the incidence and severity of lymphopenia. There is need of prospective datasets to identify the impact of radiation-related lymphopenia in GU malignancies focusing on long-term side effects, recurrence rates, and overall survival.

Topics & Keywords

Inflammatory Biomarkers in Disease Prognosis Prostate Cancer Diagnosis and Treatment Urologic and reproductive health conditions

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer Investigation

Volume 39, Issue 9, pp. 769-776

DOI: 10.1080/07357907.2021.1960992

Field-Weighted Citation Impact: 0.36

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