APE1/Ref-1 as a Novel Target for Retinal Diseases

202120 citationsJournal Articlehybrid Open Access

Authors

Curtis J. Heisel · St. Catherine University

Jonah Yousif · St. Catherine University

Mahmut Mijiti · Indiana University – Purdue University Indianapolis

Konstantinos Charizanis · Center for Independent Living

Mitchel Brigell · Ocuphire Pharma (United States)

Timothy W. Corson · Indiana University Health

Mark R. Kelley

Abstract

APE1/Ref-1 (also called Ref-1) has been extensively studied for its role in DNA repair and reduction-oxidation (redox) signaling. The review titled: “The multifunctional APE1 DNA repair-redox signaling protein as a drug target in human disease” by Caston et. al. summarizes the molecular functions of Ref-1 and the role it plays in a number of diseases, with a specific focus on various types of cancer

Topics & Keywords

Retinal Development and Disorders Retinal Diseases and Treatments Retinopathy of Prematurity Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Cellular Signaling

Volume 2, Issue 2

DOI: 10.33696/signaling.2.044

Field-Weighted Citation Impact: 1.38