Effect of Peptide Bioregulation on the State of Secretory Immunity in the Saliva of Elderly Patients with Chronic Generalized Periodontitis

Abstract—The goal of the work was to study the effect of peptide bioregulation on the mucosal immunity state of elderly patients during the complex treatment of chronic generalized periodontitis. The results were evaluated based on the saliva immunological parameters of 46 patients aged 61–69 years suffering from chronic generalized periodontitis of moderate severity before treatment and 2 months after the completion of treatment with the Vizulingval peptide complex as a peptide bioregulator. The index of oral hygiene and the intensity of gingival inflammation were studied during clinical patient examinations. A decrease in the concentration of proinflammatory cytokines IL-1β, TNF-α, and IL-8 with a simultaneous increase in the IL-10 anti-inflammatory cytokine was noted in the salivary fluid of patients subjected to bioregulatory therapy. The therapy also led to an enhancement of the local immunity of the oral mucosa, which was manifested by an increased synthesis of the secretory immunoglobulin A.