Colchicine reduces extracellular vesicle NLRP3 inflammasome protein levels in chronic coronary disease: A LoDoCo2 biomarker substudy

202161 citationsJournal Articlehybrid Open Access

Authors

Max J. M. Silvis · University Medical Center Utrecht

Aernoud T.L. Fiolet · University Medical Center Utrecht

Tjerk S.J. Opstal · Radboud University Nijmegen

Mirthe Dekker · University Medical Center Utrecht

Daniel Suquilanda · University Medical Center Utrecht

Minka Živkovic · Utrecht University

Michiel Duyvendak

Abstract

Colchicine leads to a reduction of EV NLRP3 protein levels. This indicates that inhibitory effects on the NLRP3 inflammasome might contribute to the atheroprotective effects of colchicine in coronary disease.

Topics & Keywords

Inflammasome and immune disorders Extracellular vesicles in disease Cardiovascular Disease and Adiposity

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Atherosclerosis

Volume 334, pp. 93-100

DOI: 10.1016/j.atherosclerosis.2021.08.005

Field-Weighted Citation Impact: 3.25