NAD + Redox Imbalance in the Heart Exacerbates Diabetic Cardiomyopathy

202164 citationsJournal Articlebronze Open Access

Authors

Ying Ann Chiao · Oklahoma Medical Research Foundation

Akash Deep Chakraborty · Oklahoma Medical Research Foundation

Christine Light · Oklahoma Medical Research Foundation

Rong Tian · Rutgers, The State University of New Jersey

Junichi Sadoshima

Xiaojian Shi · Guided Therapy Systems (United States)

Haiwei Gu · Guided Therapy Systems (United States)

Abstract

Our results show that NAD+ redox imbalance to regulate acetylation and phosphorylation is a critical mediator of the progression of diabetic cardiomyopathy and suggest the therapeutic potential for diabetic cardiomyopathy by harnessing NAD+ metabolism.

Topics & Keywords

Cardiovascular Function and Risk Factors Cardiac Ischemia and Reperfusion Sirtuins and Resveratrol in Medicine

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Heart Failure

Volume 14, Issue 8, pp. e008170-e008170

DOI: 10.1161/circheartfailure.120.008170

Field-Weighted Citation Impact: 6.75

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NAD <sup>+</sup> Redox Imbalance in the Heart Exacerbates Diabetic Cardiomyopathy

Authors

Abstract

Topics & Keywords

UN Sustainable Development Goals

Publication Details