TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India

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Authors

N. K. Grover · Post Graduate Institute of Medical Education and Research

Prateek Bhatia · Post Graduate Institute of Medical Education and Research

Antriksh Kumar · Post Graduate Institute of Medical Education and Research

Minu Singh · Post Graduate Institute of Medical Education and Research

Deepesh Lad · Post Graduate Institute of Medical Education and Research

Harshal Mandavdhare · Post Graduate Institute of Medical Education and Research

Abstract

NUDT15 polymorphism was more frequent than TPMT polymorphisms and was associated with thiopurine induced leukopenia. However, the tested polymorphisms account for only 24.2% of the risk of thiopurine induced leukopenia.

Topics & Keywords

Acute Lymphoblastic Leukemia research Inflammatory Bowel Disease Autoimmune and Inflammatory Disorders Research

UN Sustainable Development Goals

Partnerships for the goals

Publication Details

Published in: BMC Gastroenterology

Volume 21, Issue 1, pp. 327-327

DOI: 10.1186/s12876-021-01900-8

Field-Weighted Citation Impact: 4.12