Ruthenium(II)/Chiral Carboxylic Acid Catalyzed Enantioselective C–H Functionalization of Sulfoximines

202142 citationsJournal Article

Authors

Tatsuhiko Yoshino · Hokkaido Pharmaceutical University

Shigeki Matsunaga · Hokkaido Pharmaceutical University

Long‐Tao Huang · Hokkaido Pharmaceutical University

Yuuki Hirata · Hokkaido Pharmaceutical University

Yoshimi Kato · Hokkaido Pharmaceutical University

Luqing Lin · Hokkaido University

M. Kojima

Abstract

Abstract Ruthenium(II)-catalyzed enantioselective C–H functionalization reactions of sulfoximines with sulfoxonium ylides are described. The combination of [RuCl2(p-cymene)]2 and a pseudo-C 2-symmetric binaphthyl monocarboxylic acid furnished the S-chiral products in 76:24 to 92:8 er.

Topics & Keywords

Catalytic C–H Functionalization Methods Synthesis and Catalytic Reactions Cyclopropane Reaction Mechanisms

Publication Details

Published in: Synthesis

Volume 54, Issue 21, pp. 4703-4710

DOI: 10.1055/a-1588-0072

Field-Weighted Citation Impact: 3.80

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Ruthenium(II)/Chiral Carboxylic Acid Catalyzed Enantioselective C–H Functionalization of Sulfoximines

Authors

Abstract

Topics & Keywords

Publication Details