Oxidative Stress Resistance 1 Gene Therapy Retards Neurodegeneration in the <i>rd1</i> Mutant Mouse Model of Retinopathy

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Authors

Bhubanananda Sahu · University of Massachusetts Chan Medical School

Laura Moreno Leon · University of Massachusetts Chan Medical School

Wei Zhang · University of Massachusetts Chan Medical School

Nikita Puranik · University of Massachusetts Chan Medical School

Ramesh Periasamy · University of Massachusetts Chan Medical School

Hemant Khanna · NeuroNexus (United States)

Michael R. Volkert

Abstract

Our results suggest that OXR1 is a potential therapy candidate for retinal degeneration. Because OXR1 targets oxidative stress, a common feature of many retinal degenerative diseases, it should be of therapeutic value to multiple retinal degenerative diseases.

Topics & Keywords

Retinal Development and Disorders Retinal Diseases and Treatments Retinoids in leukemia and cellular processes

UN Sustainable Development Goals

Peace, Justice and strong institutions

Publication Details

Published in: Investigative Ophthalmology & Visual Science

Volume 62, Issue 12, pp. 8-8

DOI: 10.1167/iovs.62.12.8

Field-Weighted Citation Impact: 1.54