Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer’s disease-like neuroinflammation and cognitive impairment

2021129 citationsJournal Articlegold Open Access

Authors

Shulan Qiu · The University of Texas Health Science Center at San Antonio

Juan Pablo Palavicini · The University of Texas Health Science Center at San Antonio

Jianing Wang · Hong Kong Baptist University

Nancy S. Gonzalez · The University of Texas Health Science Center at San Antonio

Sijia He · The University of Texas Health Science Center at San Antonio

Elizabeth Dustin · Virginia Commonwealth University

Abstract

Our results strongly suggest that sulfatide deficiency is an important contributor and driver of neuroinflammation and mild cognitive impairment in AD pathology.

Topics & Keywords

Neuroinflammation and Neurodegeneration Mechanisms Alzheimer's disease research and treatments Nuclear Receptors and Signaling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Molecular Neurodegeneration

Volume 16, Issue 1, pp. 64-64

DOI: 10.1186/s13024-021-00488-7

Field-Weighted Citation Impact: 9.52