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Moral disengagement refers to a set of cognitive tactics people employ to sidestep moral self-regulatory processes that normally prevent wrongdoing. In this study, we present a comprehensive meta-analytic review of the nomological network of moral disengagement at work. First, we test its dispositional and contextual antecedents, theoretical correlates, and consequences, including ethics (workplace misconduct and organizational citizenship behaviors [OCBs]) and non-ethics outcomes (turnover intentions and task performance). Second, we examine Bandura's postulation that moral disengagement fosters misconduct by diminishing moral cognitions (moral awareness and moral judgment) and anticipatory moral self-condemning emotions (guilt). We also test a contrarian view that moral disengagement is limited in its capacity to effectively curtail moral emotions <i>after</i> wrongdoing. The results show that Honesty-Humility, guilt proneness, moral identity, trait empathy, conscientiousness, idealism, and relativism are key individual antecedents. Further, abusive supervision and perceived organizational politics are strong contextual enablers of moral disengagement, while ethical leadership and organizational justice are relatively weak deterrents. We also found that narcissism, Machiavellianism, psychopathy, and psychological entitlement are key theoretical correlates, although moral disengagement shows incremental validity over these "dark" traits. Next, moral disengagement was <i>positively</i> associated with workplace misconduct and turnover intentions, and negatively related to OCBs and task performance. Its positive impact on misconduct was mediated by lower moral awareness, moral judgment, and anticipated guilt. Interestingly, however, moral disengagement was positively related to guilt and shame post-misconduct. In sum, we find strong cumulative evidence for the pertinence of moral disengagement in the workplace. (PsycInfo Database Record (c) 2022 APA, all rights reserved).