Commensal microbe-derived acetate suppresses NAFLD/NASH development via hepatic FFAR2 signalling in mice

2021149 citationsJournal Articlegold Open Access

Authors

Ryo Aoki · Keio University

Masayoshi Onuki · Keio University

Koya Hattori · Keio University

Masato Ito · Keio University

Takahiro Yamada · Keio University

Kohei Kamikado · Ezaki Glico (Japan)

Yun‐Gi Kim · Keio University

Abstract

These findings demonstrated that the commensal microbiome-acetate-FFAR2 molecular circuit improves insulin sensitivity in the liver and prevents the development of NAFLD/NASH. Video abstract.

Topics & Keywords

Liver Disease Diagnosis and Treatment Diet, Metabolism, and Disease Gut microbiota and health

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Microbiome

Volume 9, Issue 1, pp. 188-188

DOI: 10.1186/s40168-021-01125-7

Field-Weighted Citation Impact: 14.78