Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism

2021331 citationsJournal Articlebronze Open Access

Authors

Arash Haghikia · German Centre for Cardiovascular Research

Friederike Zimmermann · German Centre for Cardiovascular Research

P. A. Schumann · German Centre for Cardiovascular Research

Andrzej Jasina · Charité - Universitätsmedizin Berlin

Johann Roessler · German Centre for Cardiovascular Research

David Schmidt · Charité - Universitätsmedizin Berlin

Philipp Heinze

Abstract

Our findings reveal a novel immune-mediated pathway linking the gut microbiota-derived metabolite PA with intestinal Npc1l1 expression and cholesterol homeostasis. The results highlight the gut immune system as a potential therapeutic target to control dyslipidaemia that may introduce a new avenue for prevention of ACVDs.

Topics & Keywords

Cholesterol and Lipid Metabolism Atherosclerosis and Cardiovascular Diseases Cancer, Lipids, and Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: European Heart Journal

Volume 43, Issue 6, pp. 518-533

DOI: 10.1093/eurheartj/ehab644

Field-Weighted Citation Impact: 40.41