Spatial Profiles of Intratumoral PD-1+ Helper T Cells Predict Prognosis in Head and Neck Squamous Cell Carcinoma

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Authors

Kanako Yoshimura · Kyoto Prefectural University of Medicine

Takahiro Tsujikawa · Oregon Health & Science University

Junichi Mitsuda · Kyoto Prefectural University of Medicine

Hiroshi Ogi · Kyoto Prefectural University of Medicine

Sumiyo Saburi · Kyoto Prefectural University of Medicine

Gaku Ohmura · Kyoto Prefectural University of Medicine

Akihito Arai

Abstract

This study reveals the significance of analyzing intratumoral cell nests and reports that an immune microenvironment with a high density of PD-1<sup>+</sup> helper T cells in tumoral cell nests is a poor prognostic factor for HNSCC.

Topics & Keywords

Cancer Immunotherapy and Biomarkers Immune cells in cancer Cancer Cells and Metastasis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Frontiers in Immunology

Volume 12, pp. 769534-769534

DOI: 10.3389/fimmu.2021.769534

Field-Weighted Citation Impact: 1.16