Rhea, the reaction knowledgebase in 2022

2021241 citationsJournal Articlegold Open Access

Authors

Parit Bansal · SIB Swiss Institute of Bioinformatics

Anne Morgat · SIB Swiss Institute of Bioinformatics

Kristian B. Axelsen · SIB Swiss Institute of Bioinformatics

Venkatesh Muthukrishnan · SIB Swiss Institute of Bioinformatics

Elisabeth Coudert · SIB Swiss Institute of Bioinformatics

Lucila Aimo · SIB Swiss Institute of Bioinformatics

Nevila Hyka‐Nouspikel

Abstract

Rhea (https://www.rhea-db.org) is an expert-curated knowledgebase of biochemical reactions based on the chemical ontology ChEBI (Chemical Entities of Biological Interest) (https://www.ebi.ac.uk/chebi). In this paper, we describe a number of key developments in Rhea since our last report in the database issue of Nucleic Acids Research in 2019. These include improved reaction coverage in Rhea, the adoption of Rhea as the reference vocabulary for enzyme annotation in the UniProt knowledgebase UniProtKB (https://www.uniprot.org), the development of a new Rhea website, and the designation of Rhea as an ELIXIR Core Data Resource. We hope that these and other developments will enhance the utility of Rhea as a reference resource to study and engineer enzymes and the metabolic systems in which they function.

Topics & Keywords

Microbial Metabolic Engineering and Bioproduction RNA and protein synthesis mechanisms Genomics and Phylogenetic Studies

Publication Details

Published in: Nucleic Acids Research

Volume 50, Issue D1, pp. D693-D700

DOI: 10.1093/nar/gkab1016

Field-Weighted Citation Impact: 12.17

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Rhea, the reaction knowledgebase in 2022

Authors

Abstract

Topics & Keywords

Publication Details