HIF-1α overexpression in mesenchymal stem cell-derived exosome-encapsulated arginine-glycine-aspartate (RGD) hydrogels boost therapeutic efficacy of cardiac repair after myocardial infarction

202160 citationsJournal Articlegold Open Access

Authors

Qingjie Wang · Changzhou No.2 People's Hospital

Le Zhang · Wuxi People's Hospital

Zhi-Qin Sun · Nanjing Medical University

Boyu Chi · Nanjing Medical University

Ailin Zou · Changzhou No.2 People's Hospital

Lipeng Mao · Changzhou No.2 People's Hospital

Xu Xiong ·

Abstract

EVs released by MSCs with HIF-1α overexpression can promote the angiogenesis of endothelial cells and the apoptosis of cardiomyocytes via upregulating the expression of miR-221-3p. RGD hydrogels can enhance the therapeutic efficacy of HIF-1α engineered MSCs-derived EVs.

Topics & Keywords

Extracellular vesicles in disease Tissue Engineering and Regenerative Medicine Cardiovascular Disease and Adiposity

Publication Details

Published in: Materials Today Bio

Volume 12, pp. 100171-100171

DOI: 10.1016/j.mtbio.2021.100171

Field-Weighted Citation Impact: 3.90

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HIF-1α overexpression in mesenchymal stem cell-derived exosome-encapsulated arginine-glycine-aspartate (RGD) hydrogels boost therapeutic efficacy of cardiac repair after myocardial infarction

Authors

Abstract

Topics & Keywords

Publication Details