FTH promotes the proliferation and renders the HCC cells specifically resist to ferroptosis by maintaining iron homeostasis

2021144 citationsJournal Articlegold Open Access

Authors

Wanye Hu · Bengbu Medical College

Chaoting Zhou · Zhejiang University of Technology

Qiangan Jing · Zhejiang University of Technology

Yancun Li · Hangzhou First People's Hospital

Jing Yang · Zhejiang Provincial People's Hospital

Chen Yang · Zhejiang Provincial People's Hospital

Lu‐Yang Wang

Abstract

These results provide new insights that FTH acts as an oncogene in the carcinogenesis and progression of HCC, and is hopeful to be a potential target for therapeutic intervention through ferroptosis.

Topics & Keywords

Ferroptosis and cancer prognosis Iron Metabolism and Disorders Trace Elements in Health

UN Sustainable Development Goals

Life below water

Publication Details

Published in: Cancer Cell International

Volume 21, Issue 1, pp. 709-709

DOI: 10.1186/s12935-021-02420-x

Field-Weighted Citation Impact: 20.40