SerpinA3N attenuates ischemic stroke injury by reducing apoptosis and neuroinflammation

202176 citationsJournal Articlegold Open Access

Authors

Yu Zhang · Shanghai Changzheng Hospital

Qianbo Chen · Shanghai Third People's Hospital

Dashuang Chen · Shanghai Changzheng Hospital

Wenqi Zhao · Shanghai Changzheng Hospital

Hao‐Wei Wang · Shanghai Changzheng Hospital

Mei Yang · Shanghai Changzheng Hospital

Zhenghua Xiang ·

Abstract

SerpinA3N is expressed in astrocytes and penumbra neurons after stroke in mice. It reduces brain damage possibly via interacting with clusterin and inhibiting neuronal apoptosis and neuroinflammation.

Topics & Keywords

Clusterin in disease pathology S100 Proteins and Annexins Alzheimer's disease research and treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: CNS Neuroscience & Therapeutics

Volume 28, Issue 4, pp. 566-579

DOI: 10.1111/cns.13776

Field-Weighted Citation Impact: 4.74