EIF4A3-Induced circARHGAP29 Promotes Aerobic Glycolysis in Docetaxel-Resistant Prostate Cancer through IGF2BP2/c-Myc/LDHA Signaling

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Authors

Xingkang Jiang · Nankai University

Shanqi Guo · First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

Shuo Wang · Nankai University

Yangyi Zhang · Second Hospital of Tianjin Medical University

Haojie Chen · Nankai University

Yong Wang · Second Hospital of Tianjin Medical University

Ranlu Liu · Second Hospital of Tianjin Medical University

Yuanjie Niu

Abstract

Upregulation of a novel circRNA, circARHGAP29, promotes docetaxel resistance and glycolytic metabolism, suggesting it could be a prognostic biomarker and therapeutic target in chemoresistant prostate cancer.

Topics & Keywords

Circular RNAs in diseases Cancer Mechanisms and Therapy Cancer-related molecular mechanisms research

Publication Details

Published in: Cancer Research

Volume 82, Issue 5, pp. 831-845

DOI: 10.1158/0008-5472.can-21-2988

Field-Weighted Citation Impact: 13.99

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EIF4A3-Induced circARHGAP29 Promotes Aerobic Glycolysis in Docetaxel-Resistant Prostate Cancer through IGF2BP2/c-Myc/LDHA Signaling

Authors

Abstract

Topics & Keywords

Publication Details