ALKBH5 Regulates SPHK1-Dependent Endothelial Cell Angiogenesis Following Ischemic Stress

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Authors

Rajesh Kumari · University of Alabama at Birmingham

Roshan Dutta · University of Alabama at Birmingham

Prabhat Ranjan · University of Alabama at Birmingham

Zainab Suleiman · University of Alabama at Birmingham

Sumanta Goswami · University of Alabama at Birmingham

Jing Li · University of Alabama at Birmingham

Harish C. Pal

Abstract

We reported that ALKBH5 helps in the maintenance of angiogenesis in endothelial cells following acute ischemic stress via reduced SPHK1 m<sup>6</sup>A methylation and downstream eNOS-AKT signaling.

Topics & Keywords

RNA modifications and cancer Cancer-related gene regulation HVDC Systems and Fault Protection

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Frontiers in Cardiovascular Medicine

Volume 8, pp. 817304-817304

DOI: 10.3389/fcvm.2021.817304

Field-Weighted Citation Impact: 4.25