Circulating Cell-Free Mitochondrial DNA in Pregnancy

202215 citationsReviewgreen Open Access

Authors

Jessica L. Bradshaw · University of North Texas

Spencer C. Cushen · University of North Texas

Nicole Phillips · University of North Texas

Styliani Goulopoulou · University of North Texas

Abstract

Circulating cell-free mitochondrial DNA (ccf-mtDNA) released upon cell injury or death stimulates diverse pattern recognition receptors to activate innate immune responses and initiate systemic inflammation. In this review, we discuss the temporal changes of ccf-mtDNA during pregnancy and its potential contribution to adverse pregnancy outcomes in pregnancy complications.

Topics & Keywords

Birth, Development, and Health Reproductive System and Pregnancy Pregnancy and preeclampsia studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Physiology

Volume 37, Issue 4, pp. 187-196

DOI: 10.1152/physiol.00037.2021

Field-Weighted Citation Impact: 5.33