EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3

2022315 citationsJournal Articlegold Open Access

Authors

Ziwen Pan · Shandong University

Rongrong Zhao · Shandong University

Boyan Li · Shandong University

Yanhua Qi · Shandong University

Wei Qiu · Shandong University

Qindong Guo · Shandong University

Shouji Zhang · Shandong University

Abstract

This work reveals that circNEIL3 plays a nonnegligible multifaceted role in promoting gliomagenesis, malignant progression and macrophage tumour-promoting phenotypes polarization, highlighting that circNEIL3 is a potential prognostic biomarker and therapeutic target in glioma.

Topics & Keywords

Circular RNAs in diseases MicroRNA in disease regulation Cancer-related molecular mechanisms research

UN Sustainable Development Goals

Life in Land

Publication Details

Published in: Molecular Cancer

Volume 21, Issue 1, pp. 16-16

DOI: 10.1186/s12943-021-01485-6

Field-Weighted Citation Impact: 26.75