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Although additive manufacturing (AM) has been maturing for some years, it has only recently started to capture the interest of the cost-sensitive construction industry. The research presented herein is seeking to integrate AM into the construction sector through the establishment of an automated end-to-end framework for the generation of high-performance AM structures, combining sophisticated optimization techniques with cutting edge AM methods. Trusses of tubular cross-section subjected to different load cases have been selected as the demonstrators of the proposed framework. Optimization studies, featuring numerical layout and geometry optimization techniques, are employed to obtain the topology of the examined structures, accounting for practical and manufacturing constraints. Cross-section optimization is subsequently undertaken, followed by a series of geometric operations for the design of free-form joints connecting the optimized members. Solid models of the optimized designs are then exported for wire arc additive manufacturing (WAAM). Following determination of the optimal printing sequence, the trusses are printed and inspected. The efficiency of the optimized designs has been assessed by means of finite element modelling and compared against equivalent conventional designs. More than 200% increases in efficiency (reflected in the capacity-to-mass ratios) were achieved for all optimized trusses (when compared to their equivalent reference designs), demonstrating the effectiveness of the proposed optimization framework.