Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer’s disease

2022111 citationsJournal Articlegold Open Access

Authors

Jiansong Fang · Cleveland Clinic Lerner College of Medicine

Pengyue Zhang · Indiana University – Purdue University Indianapolis

Quan Wang · Vanderbilt University Medical Center

Chien‐Wei Chiang · The Ohio State University

Yadi Zhou · Cleveland Clinic Lerner College of Medicine

Yuan Hou · Cleveland Clinic Lerner College of Medicine

Jielin Xu

Abstract

In summary, we present an integrated, network-based artificial intelligence methodology to rapidly translate GWAS findings and multi-omics data to genotype-informed therapeutic discovery in AD.

Topics & Keywords

Computational Drug Discovery Methods Bioinformatics and Genomic Networks Cholinesterase and Neurodegenerative Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Alzheimer s Research & Therapy

Volume 14, Issue 1, pp. 7-7

DOI: 10.1186/s13195-021-00951-z

Field-Weighted Citation Impact: 15.48